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IM wastes peptide, increases injection trauma, and requires daily dosing to achieve what SubQ delivers every 34 days

doi: 10.1016/S0003-9993(00)90052-2

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With a few notable exceptions, such as the ventral hippocampus, this projection pattern largely matches the distribution pattern of GLP1 receptorexpressing cells (Trapp & Cork, 2015), which might be indicative of these receptors throughout the CNS mainly being exposed to brainderived GLP1