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Lankisch PG, Blum T, Bruns A, Drge M, Brinkmann G, Struckmann K, Nauck MA, Maisonneuve P, Lowenfels AB

6075% of an administered dose appears in urine within 12 hours as intact peptide or amino acid metabolites

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Another reason is tolerability

Genetic Predispositions in GLP-1 Pathways and Individual Response Variability Genetic variants in GLP-1 receptor (GLP1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and appetite-regulation genes (FTO, MC4R) can influence how patients respond to semaglutide therapy

10.1080/07853890.2025.2472871 37 GuS