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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Soung A.L., Vanderheiden A., Nordvig A.S., Sissoko C.A., Canoll P., Mariani M.B., Jiang X., Bricker T., Rosoklija G.B., Arango V., Underwood M., Mann J.J., Dwork A.J., Goldman J.E., Boon A.C.M., Boldrini M., Klein R.S

Long-term treatment with inclisiran has validated the safety and effectiveness of siRNA therapy for dyslipidemia, 407 significantly advancing drug development at the RNA level

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In addition, recent studies have identified novel candidate genes, including C4A, which is involved in synaptic pruning and may influence the neurobiological mechanisms underlying depression [295]