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Direct systemic delivery : Higher concentrations reach organs like the liver and skin

No prescription formulations of copper peptide GHK-Cu have received FDA approval for any medical indication, and its use is off-label or investigational in clinical contexts

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BioMed Research International , 2014.PMID: 25276427 Gene expression study showing GHK-Cu modulates expression of 4,000+ human genes, with significant effects on DNA repair, antioxidant, and anti-inflammatory pathways

Shaw et al., 2025)