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Although direct pharmacokineticpharmacodynamic data are lacking, PD-1 receptor blockade may exert functional effects that persist for weeks or longer after drug discontinuation, creating a relatively durable window of immune hypersensitivity. Postoperative pneumonia and systemic inflammation Surgery and severe postoperative pneumonia are classic triggers of systemic inflammation and can disrupt immune homeostasis, promoting a hyperresponsive immune state (46)

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Borrelli B, et al