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Upon GABA binding, these receptors undergo conformational changes that allow chloride ions (Cl-) to enter the postsynaptic neuron

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The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

NeuroToxicology 34:189204 Mithaiwala MN et al (2021) Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications