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2013;4(5):e626
These are prescription medications requiring physician oversight, BMI eligibility criteria (typically 30 or 27 with comorbidities), and management of gastrointestinal side effects during dose escalation
The STEP clinical trial program demonstrated consistent, meaningful weight loss across thousands of participants over multiple years
Most patients start with lower doseslike 2.5 mg or 5 mgand gradually increase every few weeks as tolerated
In clinical trials, more than 85% of individuals with fatty liver experienced liver fat reduced to healthy levels, and some experienced as much as 22 to 24 percent weight loss in less than a year
Thus, future studies should consider validating the selective radioprotective potential of ebselen through rigorous pre-clinical and clinical studies
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