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Trial reports vary, with roughly 4 percent to 14 percent of participants reporting headaches, depending on the dose and study population

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Metformin has also been shown to have an anti-depressant effect in a chronic-restraint stress model of depression in mice, which is blocked by genetic knockdown of hippocampal AMPK catalytic subunits ( Prkaa1 and Prkaa2 ) [136]

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