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Ferroptosis in RM is driven by dysregulated iron metabolism and increased oxidative stress, resulting from impaired antioxidant defense, which leads to lipid peroxidation and consequent cell death in trophoblasts

reported that a panel of non-small cell lung cancer (NSCLC) cell lines exhibited heterogeneous responses to cystine starvation despite the consistent intracellular cysteine deletion and impaired GSH biosynthesis 12

Each patient was followed up until occurrence of primary outcomes, switch between SGLT2is and GLP1-RAs, discontinuation of study drugs, death, or December 31, 2019

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