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Questions still remain regarding the longevity of such transcriptional modulators in patients, yet data from a recent clinical trial of the same compound in Friedrichs Ataxia (FA), marketed as Omaveloxolone, are promising, showing significantly improved neurological function compared to placebo alongside no overt side-effects [150]

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Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial