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3.2 Cardiovascular protection 3.2.1 UA improves cardiac pump function The left ventricle must generate adequate contractile force to propel blood into the systemic circulation

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Conversely, in cancer, where autophagy is often upregulated to promote survival, inhibiting autophagy while simultaneously targeting the UPS could lead to the accumulation of toxic proteins and induce cell death

Animal studies have shown that GLP-1 promotes neogenesis and cell proliferation, inhibits apoptosis, and increases the mass of cells [6]

doi:10.1186/s12933-021-01258-x 29

GLP-1 analogs have been shown to additionally inhibit the growth of ovarian cancer cells by suppressing Akt phosphorylation [69]