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In parallel, the SURMOUNT trials, which focused on individuals with obesity with or without diabetes, revealed substantial and sustained weight loss that exceeded outcomes typically achieved with existing pharmacologic options

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You should contact your GP or healthcare provider if you notice: Lymph nodes that remain swollen for more than 3-6 weeks without obvious cause Nodes that are hard, fixed, or immobile rather than soft and moveable Progressive enlargement of lymph nodes over time Swollen nodes in multiple areas of the body simultaneously (generalised lymphadenopathy) Supraclavicular lymph nodes (above the collarbone) these are particularly concerning Nodes measuring more than 12 cm in diameter Lymph node swelling accompanied by unexplained weight loss Night sweats that soak your bedclothes Persistent fever without an obvious infection Difficulty breathing or swallowing if nodes are in the neck area Many of these features may warrant an urgent suspected cancer referral (two-week wait) as per NICE guidance