According to the MHRA product information, the most frequently reported adverse reactions include: Nausea and vomiting : Very common (affecting more than 1 in 10 people), typically most pronounced during the first 48 weeks of treatment or following dose escalation Diarrhoea : Common (affecting up to 1 in 10 people), with frequency increasing at higher doses Abdominal pain or discomfort : Often described as cramping or bloating sensations Decreased appetite : A direct result of the medication's action on satiety centres Constipation : Less common than diarrhoea but can occur in some individuals Dyspepsia (indigestion) : Characterised by upper abdominal discomfort or burning The timing of these side effects follows a predictable pattern in most patients
Specifically, individuals with the highest intake had up to 49% higher odds of diabetes compared to those who consumed the least
[DOI] [PMC free article] [PubMed] [Google Scholar] 185.Sodhi M., Rezaeianzadeh R., Kezouh A., Etminan M
Standards of Care in Diabetes2025
He explained: Thats what surprised me
While gastrointestinal side effects like nausea and diarrhea are well-documented, some patients report experiencing leg cramps during treatment
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