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Other studies identified H3K27me3 demethylase, KDM6A/UTX as a metformin target based on a structure- and ligand-based bioinformatic analysis ( Figure 2 Absorption and distribution of metformin Metformin is used at daily doses of 3050 mg/kg body weight to treat type II diabetes, reaching serum levels of 1040 M ( Species-specific differences show that mice are ~10 times less sensitive to metformin than humans ( Once in plasma/serum, metformin reaches the intracellular milieu via a limited passive diffusion, while other studies indicated that cationic transporters (Organic Cation Transporter 1: OCT1, OCT2, and MATE1) are able to transport metformin intracellularly ( Metformin's potential impact on infertility The bioenergetic, metabolic processes indicated above are critical to sustain a physiological function of the male and female gonads, therefore, in the following sections, we summarize the current knowledge on metformin in regard to its effects on the reproductive processes of males and females in humans and across species

A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity (de Benoist, 2008)

Mol Cells (2018) 41(3):23443

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