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Exposure to arsenic (As) leads to an increase in the generation of ROS and raises the levels of heme oxygenase (HMOX1), a crucial modulator of heme oxidation and reaction to stress in kidney epithelial cells (49)

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We also performed quantitative kinetic measurements at pH 6.0 (pH 7.0 was not possible for technical reasons explained in Methods

Many studies emulated the definition of DR complications in the SUSTAIN 6 trial, while others measured the incidence of new DR, PDR, or DME

In this structural sense, AOD-9604 succeeded

Accessed 8/15/2015