Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1
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This multi-parameter parallel monitoring capability elevates AST from the traditional endpoint phenotypic assessment of growth or no growth to a dynamic, mechanistic-level analysis of how the antibiotic acts
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For example, intracellular Ca 2+ overload induces a transient oxidative stress in the organism and promotes the generation of ROS, which activate injurious signaling through transient receptor potential subtype anchor protein 1 channels (Takano et al., 2007)
Alcoholism: Clinical and Experimental Research
