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Compelling pieces of evidence have shown that n-3 intake, including maternal n-3 consumption, has beneficial effects in alcohol-elicited neurodegeneration, particularly in FASD, and alcoholic liver damage, also improving alcoholic gastric hemorrhage (67), pancreatitis (68) and angiogenesis (55) (Supplementary Table 1)

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Besides chemicals in tobacco also antimalaria-drugs cause an oral pigmentation

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Whether a possible positive feedback loop includes NPY as well is not known, but the system is no doubt more complicated than presented here