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NNMT normally methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine

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This, of course, doesnt necessarily mean that the low B12 is whats causing the weight gain

Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research

Some common symptoms of vitamin B12 deficiency include Vitamin B12 is essential for the production of red blood cells, and a deficiency can lead to anemia, which can cause fatigue and weakness