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low background concentrations can be detected in soils, sediments, waters and even in organisms

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10.1016/j.biomaterials.2020.119844 Biomaterials 198 YangW.TuZ.SunQ.LiX

6.3 The kynurenine pathway: an interactive mechanism linking gut microbiota, immunity, and neurotransmitters Specific neurotransmitters, such as GABA, dopamine, glutamate, and serotonin (5-HT), are derived from precursors tyrosine and tryptophan, which are transported across the BBB into the CNS and subsequently converted into neurotransmitters (213)

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Chronic stress elevates cortisol, a hormone that promotes fat storage in the abdominal region