More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]
However, research has not confirmed these effects in humans, so its anti-aging benefits remain unproven
For one thing, it is a well-known anti-diabetic spice
While no conclusive evidence links hormonal fertility treatments to increased breast, colon, cervical, or endometrial cancer risk, ovarian cancer risk may be modestly increased, potentially confounded by underlying conditions such as endometriosis or nulliparity
Certain medications like chemotherapy can cause hair loss, too
8.2 Lactation Risk Summary There is no information regarding the presence of dapagliflozin in human milk, the effects on the breastfed infant, or the effects on milk production
