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Similarly, mucoadhesive polymers that interact with mucin are employed to prolong nanoparticle residence in the nasal passage

That's why it shows up so often as a reference peptide in this kind of work

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If it's off by even a fraction, the whole structure is compromised

Under normal circumstances, insulin maintains the NAD(+)/NADH ratio by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway and inhibiting the forkhead box protein O1/heme oxygenase 1 (Foxo1/Hmox1) pathway, thereby mediating the activation of the sirtuin 1/peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (SIRT1/PGC-1) pathway and regulating mitochondrial physiological functions (27)

Cell Death Dis 14 , 131 (2023)