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When we say the evidence shows this works, who was actually included in that evidence

The NHS does not set an upper safe limit for B12 because harmful effects from excessive intake have not been definitively established

In exploring the potential therapeutic agents for IBD, a study reports a variety of polyphenolic substances, phenolic compounds, alkaloids, storage polysaccharides, phytochemicals, and antioxidant hormones, such as resveratrol, curcumin, quercetin, berberine, tamarind xyloglucan, sulforaphane, ginger, and melatonin (196)

[11] In clinical research settings and certain intensive protocols (such as addiction detoxification), much higher NAD+ dosages have been utilized

We assume that the exon 35 deletions with notation c.11381-?_11524+?del, detected via MLPA, and the c.11435_11524+30del variant, detected via NGS, 8 are likely the same variant