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When stomach acid hits the esophageal tissue, it triggers the production of reactive oxygen species (ROS)

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In this period, since the syncytiotrophoblast cells do not express the antioxidant mitochondrial superoxide dismutase (SOD), ROS levels are high, inducing the production of factors that regulate cell proliferation and angiogenesis, such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), which are abundantly expressed in the placenta [20]

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MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene

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