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7 In a 72-week study, tirzepatide, a GLP-1/ GIP receptor agonist, was more effective at achieving weight loss (20% reduction in body weight) when compared to studies of conventional GLP-1 receptor agonists (15% reduction in body weight)
However, when the body produces too much uric acid or the kidneys excrete too little, levels can rise, increasing the risk of gout
S.MorrisonE.SmirnovaT
therefore, mice with significantly greater weights (20% above the average weight of all enrolled mice) were excluded
19,20 Retatrutide, a triple GLP-1/GIP/glucagon agonist, has demonstrated the greatest reported efficacy to date, with weight loss reaching approximately 24.2% in adult clinical trials
A.LevineJ
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