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Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) New England Journal of Medicine 68-week trial of 1,961 adults showed semaglutide 2.4 mg weekly achieved 14.9% mean body weight loss versus 2.4% with placebo, establishing landmark weight management efficacy

J Neurol Neurosurg Psychiatry 76(8):10461057

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Glossary of Terms Adaptive Thermogenesis The bodys natural response to prolonged caloric deficit where metabolic rate decreases beyond what would be predicted from weight loss alone