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Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

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PubMed Central , Clinical and Experimental Gastroenterology , vol

Furthermore, GLY dose-dependently upregulated PI3K, Akt, and Bcl-2 expression, while downregulating NF-B p65 and Bax compared with the untreated MI/R group