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NADPH acts as a cofactor and reducing agent for enzymes such as glutathione reductase and thioredoxin reductase, catalyzing the reduction of glutathione (GSH) and thioredoxin (Trx), respectively (Figure 1)

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Metabolic Factors : Conditions such as obesity, diabetes, and kidney disease can affect the body's ability to manage uric acid levels

Hepatocyte-specific SIRT1 knockout mice exhibit impaired glucose tolerance, decreased insulin sensitivity, and elevated HOMA-IR values, supporting a protective role of SIRT1 in hepatic glucose homeostasis

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In addition to analysis in blood and urine, acylcarnitine profiling can also be done in cultured fibroblasts after a fatty acid loading test [41]