More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27
Darnell M, Breitholtz K, Isin EM, Jurva U, Weidolf L
Thymosin alpha-1 is often considered the most logical starting point due to its well-established safety profile, its direct immune-modulatory mechanism, and the finding that lupus patients tend to have lower endogenous levels
13 FiedorJ.BurdaK
ACE2 counters the action of ACE and causes decrease in angiotensin II and increase in angiotensin (17)
The result is improved tissue health, faster recovery, and a renewed capacity for regeneration, offering hope for age-related conditions (4)