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MATERIAL AND METHODS Animals Wistar Albino male rats (200 g b.w.) were randomly assigned to the experiments (10 animals, at least, per each experimental group), all of which were approved by the Local Ethics Committee

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Moreover, structural superposition between GSH-bound OsDHAR and glutathione disulphide (GSSG)-bound hGSTO1-1 showed dramatic helix (5, 6 and 9) movement in the C-terminal domain region of OsDHAR, which likely allows bound GSH molecules in the G- and H-sites to be sufficient close for GSSG formation (Supplemental Fig

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Mol Cancer (2019) 18(1):64