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Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication

Ozempic and Wegovy are generally considered safe and effective medicines, and the vast majority of patients benefit from their use without experiencing serious side effects

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Apomorphine, as a non-selective agonist, activates both D2-like and, to a much lesser extent, D1-like receptors [162]