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Combination Weight Loss (CagriSema) Extensive Research The Phase 3 REDEFINE 1 trial demonstrated that CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) produced mean weight loss of 20.4% at 68 weeks in 3,417 adults with obesity or overweight without diabetes, compared to 14.9% with semaglutide alone, 11.5% with cagrilintide alone, and 3.0% with placebo

(1) Assessing fatty acid oxidation using addition of sequential substrates, (2) Mitochondrial respiration analysis with MiR05 respiration medium and sequential substrates, and (3) Assessment of complex II function using MiR05 supplemented with rotenone and complex II specific substrates

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