Schisano B, Harte AL, Lois K, Saravanan P, Al-Daghri N, Al-Attas O, Knudsen LB, McTernan PG, Ceriello A, Tripathi G: GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
2015 Sep 15;97(2):173-7
To be market-worthy, the drug needed to remain active 24 hours a day, remain physically stable for long periods of time and be as or more potent than native GLP-1
Tailoring a molecule to this specific purpose requires a substantial understanding of how the current class of GLP-1R agonists access and interact with the satiating and aversive neuronal receptor populations
Some people lose significantly more
This surge is driven by blockbuster products like Novo Nordisks Wegovy (semaglutide) and Eli Lillys Mounjaro/Zepbound (tirzepatide), whose weight-loss sales doubled or more year-over-year ( [3] ) ( [4] )