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Semaglutide is a synthetic version of the GLP-1 hormone that is naturally produced in your intestines

10.1016/j.febslet.2008.07.044 34

(source: sec.gov) January 2026 : Novo Nordisk announced the broad availability of the Wegovy pill across America

What to Expect When Microdosing GLP-1 Since titration (gradually increasing the dose) is slower with microdosing, the overall timeline often looks different than standard protocols

With increasing weight loss, osteoporosis risk increased in both groups, and the GLP-1 risks were generally similar to or higher than the non-GLP-1 weight loss medication risks

Yu JH, Kim KH, Kim H (2008) SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas