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Topical methimazole, although not allowed in cosmetics, did not induce melanotoxicity or changes in thyroid functions [78, 98], and was proven to be a useful alternative treatment in some melasma cases [97]

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The transporter system Xc- imports extracellular cystine, while it exports intracellular glutamate at a 1:1 ratio [38, 39]

54 Microbial characteristics of HCC Gut microbial dysbiosis in HCC integrates the characteristics of its underlying liver disease (such as viral hepatitis, cirrhosis, and MASLD) and further develops specific patterns related to the tumor immune microenvironment and treatment response

In contrast, after the addition of SB431542, a TGF signalling inhibitor, to the high-glucose medium, -SMA expression in PSCs decreased to a nearly undetectable level