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[1] [3] The injection bypasses the gastrointestinal tract entirely, making it particularly effective for patients with absorption problems such as pernicious anaemia or those who have undergone gastric surgery

PMID 26334606

1 In addition, as many as 1 in 5 older patients may be unable to generate sufficient peak inspiratory flow rates (PIFR) for successful use of a DPI

I apply it straight after cleansing my skin and before my moisturiser