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This lack of oxygen damages the nerve permanently, resulting in sudden, painless, and typically irreversible vision loss in one eye

ATP citrate lyase (Acly) is a key metabolic enzyme that converts mitochondria-derived citrate into acetyl-CoA and oxaloacetate within the cytosol

MiR-27a inhibits the expression of several lipid metabolic genes, including SREBP1-2, FASN, and PPAR/, by reducing lipid synthesis and increasing lipid secretion from cells 92

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