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Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102

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Witschi, A., Reddy, S., Stofer, B

Importantly, the trial was designed for non-inferiority rather than superiority and its relatively small sample size and short duration limit conclusions about long-term efficacy and safety

C., Han, S