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In severe cases of deficiency, our experienced healthcare providers may recommend an initial treatment plan that involves frequent injections, potentially daily or every other day, for one to two weeks

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These symptoms may be very similar to the symptoms of spinal stenosis (spinal claudication), and tests on the blood supply to the legs may be needed to determine which is causing the symptoms

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Mechanistically, this was associated with increased expression/internalization of VEGFR2 and activation of downstream Akt-eNOS signaling (Hsieh 2017)