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As with any prescription medication, some patients may experience mild side effects like nausea, constipation, or fatigue

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This supports the assumption that the substance class, not the route of administration, dominates the side-effect pattern

Meanwhile, a wealth of literature has long been available about the biotransformation of xenobiotics, notably by gut bacteria (reviewed in Sousa et al., 2008

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Rather than trying to force a peptide through the gastrointestinal barrier using formulation technology, several research groups asked whether a small, non-peptide molecule could be designed to activate the GLP-1 receptor directly