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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

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Furthermore, if the drugs or chemicals are similar to endogenous substances, they can also use active placental transporters for their transport, which may considerably affect the exposure of the fetus to them, but also the treatment of a sick fetus

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