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It is essential to distinguish between a genuine plateau and the expected tapering of weight loss velocity that occurs with all anti-obesity medications

Certain individuals, such as those with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2 syndrome, or specific gastrointestinal disorders, might need to explore alternatives to semaglutide

The titration schedule is different

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Rapid clearance necessitates frequent dosing, which may reduce patient compliance