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The burning of tobacco produces ROS in the gas phase inhaled by smokers, as part of the mainstream smoke ( 2 to or additional free radicals like H 2 O 2 and OH ( Increasing data indicate that the release of ROS from smoking and the subsequent oxidative stress have a substantial impact on inflammation and carcinogenesis

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PMID: 95 YaoFPengJZhangEJiDGaoZTangYet al

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The notation c.11381-?_11524+?del describes a deletion of exon 35 detected via MLPA with the ? indicating that it is unknown how far into the neighboring introns the deletion extends