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They stated that the lower enzyme activity in the HBV-infected carcinoma tissue resulted from a further disruption in the antioxidant defense system (double insults of hepatocellular carcinoma and HBV infection)
The oxidative stress-induced weakening of the fibrous cap covering the plaque, due to the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), is a key factor in plaque instability [75]
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doi: 10.3390/antiox10060837