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Parasutterella colonization has been shown to alter tryptophan, tyrosine, and xanthine metabolism in mouse cecal samples 61

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TNF- Inhibitor Therapy Restores Cytokine Balance and Normalizes Organ Function TNF- inhibitors can counteract the entire disease process in patients with chronic inflammatory diseases (e.g., RA, psoriatic arthritis (PsA), CD, and ulcerative colitis (UC)) by fundamentally modulating the molecular and cellular changes of several inflammatory networks of the innate immune system [6,10,16,17,29,30,31]