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KPV is small enough at just 342 daltons to be recognized and transported directly into the cell via PepT1.2 This matters clinically for one specific reason: PepT1 expression is significantly upregulated in inflamed intestinal tissue.2 The more inflamed the gut, the more actively it imports KPV

Faizy et al., 2020)

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The half-life of cagrilintide is 159-195 hours (approximately 6.6 to 8.1 days) making it suitable for once weekly subcutaneous administration [5]

Voronina OL, Kunda MS, Ryzhova NN, Aksenova EI, Sharapova NE, Semenov AN, Amelina EL, Chuchalin AG, Gintsburg AL