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Any decision to continue or discontinue therapy should be made collaboratively between patient and provider, considering the totality of available evidence and individual circumstances

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The exploration of new therapeutic targets, the development of predictive tools for treatment response, and the refinement of guidelines for combined therapy will be critical in enhancing care for patients with coexisting conditions

Thyroid Function The silymarin in milk thistle may affect thyroid function, though clinical significance is unclear [1][51]