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Nevertheless, utilising these liposomes in cancer gene therapy faces limitations, both extracellular and intracellular, compromising their effectiveness [76, 77] Additionally, cationic liposomes have been found to enhance chemiluminescence reactions, and their positive charge plays a significant role in this process [78]

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A.SarismailoluR.et al

However, tumor cells also continuously shed MPs from their surfaces, and evidence suggests that tumor cellderived MPs are involved in the development of MDR, transferring functional resistance proteins from donor-resistant cells to drug-responsive cells in as little as several hours (303, 371, 372)