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Circulating fibroblast growth factor 21 (FGF21) is also implicated in glucagon-induced energy expenditure, as mice lacking FGF21 are protected from this effect [62]

This can disrupt growth and development, raise homocysteine and affect cognitive and cardiovascular health

Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up

C., Lee, I

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However, a 2025 study found that people who used weight-loss medication regained weight more rapidly, with an average monthly weight regain of 0.4kg compared with 0.1kg in those who followed behavioural weight management programmes