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La activacin de GLP-1R en clulas pancreticas potencia la secrecin de insulina dependiente de glucosa y suprime glucagn, mientras que la sealizacin GLP-1R en ncleos hipotalmicos (arcuato, NTS) reduce la ingesta calrica

The most commonly reported adverse events included: Diarrhea Dizziness No significant excess safety concerns were identified during the pivotal clinical trials

S2CID 20214857

Important safety considerations include risks of acute pancreatitis, gallbladder disease, and acute kidney injury (particularly from dehydration)

These reactions are usually mild and go away on their own

It functions by inhibiting the NNMT enzyme, which may contribute to increased cellular NAD levels, a key factor associated with improved metabolism and body composition outcomes