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Doxycycline belongs to the tetracycline series of antibiotics that are used to treat multiple infections all over the body

Nitrosative stress and cytokines are linked with the severity of sepsis and organ dysfunction

The issues linked to the pH measurement of ultrapure water are addressed in various references

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Several techniques have been developed for the evaluation of the BBB such as the in vivo brain uptake index (BUI) method (88), in situ brain perfusion (89), cerebral microdialysis technique (90, 91), and cell uptake studies in the in vitro models of the BBB (92)